Topical anesthesia with or without propofol sedation versus retrobulbar/peribulbar anesthesia for cataract extraction - Prospective randomized trial

Purpose: To evaluate the feasibility of intravenous sedation in addition to topical anesthesia during cataract extraction. Setting: Helsinki University Eye Hospital, Helsinki, Finland. Methods: Three hundred seventeen eyes of 291 consecutive patients having ca taract surgery were prospectively randomized to receive topical (oxybuproca ine 0.4%, n = 96), combined (topical anesthesia and propofol sedation, n = 107), or retrobulbar/peribulbar (prilocaine 1.5%, n = 114) anesthesia. The intraoperative conditions were judged by the surgeon. A numerical scale (0 to 10) was used to assess the degree of pain during surgery. Outcome measur es were the number of complications and adverse events registered periopera tively and 1 week postoperatively as well as Snellen visual acuity. Results: The success of posterior chamber intraocular lens (IOL) implantati on through a self-sealing clear corneal incision was 97.9%, 96.3%, and 98.2 % in the topical, combined, and retrobulbar/peribulbar groups, respectively . There was no difference among the groups in pain during surgery, frequenc y of complications, or outcome measures. One week postoperatively, visual a cuity was 20/40 or better in 81.7%, 78.5%, and 77.5% of eyes in the topical , combined, and retrobulbar/peribulbar groups, respectively. The surgeon re ported significantly fewer difficulties in the retrobulbar/peribulbar group (9.8%) than in the topical (26.0%) (P = .004) or combined (21.0%) (P = .03 6) groups, Additional sedative/analgesic medication given intraoperatively was required significantly more often in the topical (15.6%) than in the re trobulbar/peribulbar group (2.6%) (P = .002). Patients with bilateral surge ry preferred combined anesthesia over retrobulbar/peribulbar anesthesia; ho wever, there was no significant difference in patient acceptance among grou ps in patients having unilateral surgery. Conclusion: Intravenous propofol sedation added to topical anesthesia did n ot improve the operative conditions or surgical outcome. Retrobulbar/peribu lbar anesthesia ensured the best surgical conditions. Patients in all anest hesia groups reported high satisfaction. However, patients having bilateral surgery seemed to prefer combined anesthesia over retrobulbar/peribulbar a nesthesia. (C) 2001 ASCPS and ESCRS.