Optic neuropathy in primary antiphospholipid syndrome in childhood

Neurologic symptoms associated with antiphospholipid antibodies in children include thrombotic events, unilateral movement disorders, or migraine. We present a 7-year-old girl with bilateral optic neuropathy, cerebral white-m atter lesions, and antiphospholipid IgM that responded to prednisone mid te nded to relapse when it was stopped. Remission was obtained under maintenan ce corticosteroid therapy, and the antiphospholipid antibodies disappeared. This case suggests a role for antiphospholipid antibodies in the pathogene sis of optic neuropathy in childhood.