Absence of hippocampal sclerosis in children with multiple daily seizures since infancy

We report a series of nine children with multiple daily seizures since infa ncy who underwent functional hemispherectomy that included en bloc resectio n of the hippocampus and the temporal neocortex. In all cases, the hippocam pi were normal by conventional histology despite the fact that these patien ts had suffered from recurrent seizures over a long period of time. This ob servation suggests that extremely frequent seizures in childhood are not in variably associated with the development of hippocampal sclerosis.