Neurofibromatosis type 1 presenting with hand dystonia

Neurofibromatosis type 1 is frequently associated with increased intensity T-2-weighted magnetic resonance imaging (MRI) brain abnormalities, called " unidentified bright objects." Unidentified bright objects are generally hel d to be benign and tend to decrease in size during adulthood. We describe a case of neurofibromatosis type 1 with a similar thalamic and subthalamic M RI abnormality associated with contralateral hand dystonia. Over a 2-year f ollow-up, the lesions showed a reduction in size apparently correlated with a reduction in symptoms.