Nasal midazolam effects on childhood acute seizures

Sixteen children, aged from 2 months to 14 years, with a diagnosis of acute seizures and seen at Dr. Sami Ulus Child Health and Disease Center, were i ncluded in this study. Midazolam. (5 mg/mL) 0.2 mg/kg was administered intr anasally in 30 seconds by an injector. The heart rate, respiratory rate, bl ood pressure, and oxygen saturation were recorded at 0, 5, and 10 minutes a fter administration. The seizures of three (18.7%) patients terminated with in I minute, of seven (43.7%) patients in I to 2 minutes, and of three (18. 7%) patients in 2 to 5 minutes. However, three (18.7%) patients did not res pond to treatment. As a result, it was concluded that intranasal midazolam administration is easy and effective. The half-life of midazolam is shorter than diazepam, and midazolam has fewer complications when compared with di azepam. It is easier to use in nasal drop and spray forms.