Migrating partial seizures in infancy: Two new cases

Two infants presented at 3 weeks and 3 months of age with intractable parti al seizures. Extensive investigations failed to identify an underlying caus e. There was no response to antiepileptic drug therapy and no developmental progress following the onset of the seizures. In both infants there was a distinctive pattern of seizures that arose independently from multiple regi ons of both hemispheres. Interictal electroencephalograms revealed multifoc al epileptiform activity. The infants died aged 9 and 12 months. One underw ent postmortem examination, which was normal with no hippocampal sclerosis. These infants fulfill the diagnostic criteria of the syndrome of migrating partial seizures in infancy described by Coppola and colleagues in 1995.