Do steroids help jaundice caused by primary sclerosing cholangitis?

The management of jaundice in patients with primary sclerosing cholangitis (PSC) is clinically challenging. In patients in whom the recognized precipi tants for jaundice have been excluded, the outlook is uncertain at best. So me improve spontaneously, but the only treatment demonstrated to be effecti ve is liver transplantation-which may not always be appropriate. We report three cases of jaundice in patients with PSC in whom corticosteroid therapy appeared to be beneficial.