The objectives of this analysis were to determine the prevalence of oral mu
cosal lesions (OML) among adults in Southern China and to determine possibl
e associations between OML and reported tobacco-smoking and alcohol-drinkin
g habits. The sample consisted of 1573 35- to 44-year-old and 1515 65- to 7
4-year-old Chinese from both urban and rural areas of Guangdong Province. T
he subjects were interviewed by trained interviewers and underwent a clinic
al examination of the oral mucosa performed according to WHO guidelines. A
specially prepared color atlas of OML was used for lesion recognition and c
onfirmation during the survey. Among the 35- to 44-year-old subjects, the o
verall prevalence of OML was found to be 13% in urban men, 6% in urban wome
n, 15% in rural men, and 4% in rural women. The corresponding figures for t
he 65- to 74-year-olds were 22%, 12%, 26%, and 19%. Tongue lesions and whit
e lesions were relatively common, but denture-related lesions were not. No
malignancies or erythroplakia was observed. Age and gender were found to re
late to the occurrence of OML. In elderly men, smoking was significantly (p
<0.05) associated with some white lesions and tongue lesions, and alcohol d
rinking was also associated with some white lesions. In conclusion, tongue
lesions and white lesions were relatively common in men, but pre-cancerous
lesions were not prevalent.