In situ hybridization analysis of preprotachykinin-A mRNA levels in young and old rats

Authors
Pompei, P Severini, R Pediconi, D Martarelli, D Massi, M Fattoretti, P Bertoni-Freddari, C
Citation
P. Pompei et al., In situ hybridization analysis of preprotachykinin-A mRNA levels in young and old rats, J HIST CYTO, 49(10), 2001, pp. 1325-1326
Citations number
8
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
ISSN journal
00221554 → ACNP
Volume
49
Issue
10
Year of publication
2001
Pages
1325 - 1326
Database
ISI
SICI code
0022-1554(200110)49:10<1325:ISHAOP>2.0.ZU;2-V
Abstract
Preprotachykinin-A (PPT-A) mRNA levels in discrete rat brain regions were e xamined. Analysis of silver grains revealed a 19.2% and 31.5% statistically significant decrease in PPT-A mRNA in the dorsal and ventral caudate putam en (d-CPu and v-CPu), respectively, a 30% lower expression of PPT-A mRNA in the bed nucleus of the stria terminalis (BNST), a 33.7% decrease in PPT-A mRNA in the habenula (Hb), and a 30% decrease of PPT-A mRNA levels in the p osterodorsal part of the medial amygdala (MePD). Results show that aging of the CNS is associated with widespread changes in tachykinin gene expressio n, suggesting that alterations in the tachykinergic system may have implica tions in the physiopathology of the elderly.