Deep Brain Stimulation (DBS) attentional effects parallel those of l-dopa treatment

Authors
Brusa, L Pierantozzi, M Peppe, A Altibrandi, MG Giacomini, P Mazzone, P Stanzione, P
Citation
L. Brusa et al., Deep Brain Stimulation (DBS) attentional effects parallel those of l-dopa treatment, J NEURAL TR, 108(8-9), 2001, pp. 1021-1027
Citations number
33
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEURAL TRANSMISSION
ISSN journal
03009564 → ACNP
Volume
108
Issue
8-9
Year of publication
2001
Pages
1021 - 1027
Database
ISI
SICI code
0300-9564(2001)108:8-9<1021:DBS(AE>2.0.ZU;2-5
Abstract
Aim of our study was to investigate the different effects on attentional ca pacity of deep brain stimulation DBS (STN or GPi) and of 1-dopa in PD patie nts. Patients were evaluated on-DBS/off-1-dopa, on-1-dopa/off-DBS, on-1-dop a/on-DBS and off-1-dopa/off-DBS. Our results indicate that DBS effects on a ttentional functions parallel those of 1-dopa. A site independent (both STN and GPi) worsening of verbal fluency was observed, possibly connected to t he stimulus effect on the cortico-subcortical-cortical loop.