Automation of organic synthesis on the basis of integrated chemical process

The automation of multi-step chemical processes has been realized. A new co ncept for one-pot processes has been advanced which enables integration of various types of reactions involving carbon-carbon bond formations and func tional group modifications. In the meantime, an automated synthesizer to ac commodate such one-pot processes has been devised. This machine allows us t o reproduce usual bench work: treatment of air-sensitive materials, control of temperature from -78 degreesC to 100 degreesC within +/-0.1 degreesC ac curacy, and successive addition of reagents. Several examples which were su ccessfully conducted on the machine are described.