A NEW METHOD FOR ABSOLUTE QUANTITATION OF MRS METABOLITES

A new method for absolute quantitation of MRS spectra is presented. Th is method is not based on a reference peak, derived from a real NMR si gnal, but rather on a synthesized NMR reference produced by an electro nic device, transmitted by a broad-band antenna to avoid quality facto r variations. This signal is therefore received at the same time as th e sample signal. The reference line produced is stable in time (maximu m variation lower than 2%) and allows precise and accurate measurement of absolute concentrations (mean error lower than 3%) in vitro and in vivo.