Short daily hemodialysis rapidly improves nutritional status in hemodialysis patients

Background. Malnutrition is a common problem in maintenance hemodialysis pa tients and is associated with increased mortality and morbidity, Interventi ons such as oral or intravenous nutritional supplements have often failed t o improve nutritional status. We studied the effect of a daily dialysis pro gram on nutritional parameters. Methods. Eight patients treated with standard hemodialysis (SHD) 4 to 5 hou rs three times per week were converted to daily hemodialysis (DHD) 2 to 2.5 hours six times per week. Serum albumin, prealbumin, and total cholesterol were evaluated every three months, Anthropometry and dietary evaluation we re performed every six months. Results. Serum albumin rose from 39.0 +/- 2.6 to 42.0 +/- 3.1 and 43.0 +/- 2.6 g/L, prealbumin from 0.36 +/- 0.04 to 0.41 +/- 0.05 and 0.42 +/- 0.1 g/ L, total cholesterol from 1.7 +/- 0.4 to 1.9 +/- 0.4 and 1.8 +/- 0.3 g/L at baseline and at 6 and 12 months, respectively, after switching patients to DHD. Daily protein intake increased from 1.29 +/- 0.20 g/kg/day to 1.48 +/ - 0.60 and 1.90 +/- 0.70 (P < 0.05). These changes were accompanied by a dr y body weight increase of 2.4 +/- 1.6 kg (P < 0.005) at month 6 and 4.2 +/- 2.8 kg at one year (P < 0.05). Lean body mass increased from 47.7 +/- 4.9 kg to 49.1 +/- 5.9 (P < 0.05) and 50.5 +/- 6.2 (P < 0.05). Conclusions, Daily hemodialysis appears to be a suitable method to improve nutritional status in maintenance dialysis patients.