CHARACTERISTICS AND SIGNIFICANCE OF BRAIN N-METHYL-D-ASPARTATE (NMDA)RECEPTORS

Since the discovery of the brain receptors for the excitatory amino ac id neurotransmitters in the mid-sixties, significant progress has been made in the study and discovery of several classes of these receptors ; of which the N-methyl-D-aspartate (NMDA) is the most extensively stu died, The characteristic and neurophysiological role of these receptor s NMDA receptors and outline the progress made in this field with refe rence to possible clinical applications of some modulators of these re ceptors in the treatment of some forms of epilepsy, Parkinsonism, Alzh eimer's disease, amyotrophic lateral sclerosis and possibly in other n eurological disorders.