Influence of hypothalamic proline-rich peptide on the level of [C-14]glucose utilization during Crush syndrome

The number of publications on the investigation of crush syndrome (CS) path ogenesis at traumatic toxicosis is rather limited. The influence of some ph armacological preparations on the development of CS pathogenesis is not ver y well clarified. Proline-rich peptide (PRP) is a fragment of a glycopeptid e comprising the carboxyterminus of the neurohypophyseal vasopressin-neurop hysin precursor isolated from the bovine neurohypophysis neurosecretory gra nules. The polypeptide possesses stimulating activity on differentiation an d proliferation of T-lymphocytes and Interleukin-2 (II-2) biosynthesis. The experimental model of CS of white rats was induced by 2-h of compression f ollowed by 2, 24, and 48-h of decompression of femoral muscle tissue. The i nfluence of PRP on [C-14]glucose utilization was investigated in brain, hea rt, and kidney tissues. The level of [C-14]glucose utilization decreased in brain during compression followed by 2-h and 24-h of decompression, while it increased under the influence of PRP at all decompression periods. The i nfluence of PRP on the myocardium and kidneys differs, depending on its nat ure and on the periods of decompression.