Ga. Kevorkian et al., Influence of hypothalamic proline-rich peptide on the level of [C-14]glucose utilization during Crush syndrome, NEUROCHEM R, 26(7), 2001, pp. 829-832
The number of publications on the investigation of crush syndrome (CS) path
ogenesis at traumatic toxicosis is rather limited. The influence of some ph
armacological preparations on the development of CS pathogenesis is not ver
y well clarified. Proline-rich peptide (PRP) is a fragment of a glycopeptid
e comprising the carboxyterminus of the neurohypophyseal vasopressin-neurop
hysin precursor isolated from the bovine neurohypophysis neurosecretory gra
nules. The polypeptide possesses stimulating activity on differentiation an
d proliferation of T-lymphocytes and Interleukin-2 (II-2) biosynthesis. The
experimental model of CS of white rats was induced by 2-h of compression f
ollowed by 2, 24, and 48-h of decompression of femoral muscle tissue. The i
nfluence of PRP on [C-14]glucose utilization was investigated in brain, hea
rt, and kidney tissues. The level of [C-14]glucose utilization decreased in
brain during compression followed by 2-h and 24-h of decompression, while
it increased under the influence of PRP at all decompression periods. The i
nfluence of PRP on the myocardium and kidneys differs, depending on its nat
ure and on the periods of decompression.