Apolipoprotein E genotype, coagulation, and survival following acute stroke

The authors hypothesized that divergent influences of the APOE epsilon4 all ele on ischemic and hemorrhagic stroke survival might result from differenc es in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 car riers had higher partial thromboplastin time ratios (p < 0.01) than non-eps ilon4 carriers. Among 529 ischemic stroke patients, increasing epsilon4 all ele dose was associated with improved survival (p = 0.03) after adjusting f or baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survi val advantage in epsilon4-carrying ischemic stroke patients.