Intra-arterial urokinase for acute ischemic stroke: Factors associated with complications

Authors
Tirschwell, DL Coplin, WM Becker, KJ Vogelzang, P Eskridge, J Haynor, D Cohen, W Newell, D Winn, HR Longstreth, WT
Citation
Dl. Tirschwell et al., Intra-arterial urokinase for acute ischemic stroke: Factors associated with complications, NEUROLOGY, 57(6), 2001, pp. 1100-1103
Citations number
9
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
6
Year of publication
2001
Pages
1100 - 1103
Database
ISI
SICI code
0028-3878(20010925)57:6<1100:IUFAIS>2.0.ZU;2-V
Abstract
The authors abstracted the records of 43 patients treated with intra-arteri al urokinase for acute ischemic stroke to identify predictors of serious co mplications. Sixteen (37%) had such a complication. Higher urokinase dose ( >1.5 X 10(6) U), higher mean arterial blood pressure before treatment (> 13 0 mm Hg), basilar occlusive strokes, and severe strokes were most predictiv e of these complications. Although urokinase is no longer manufactured, the se findings identify patients at risk for complications from other intra-ar terial thrombolytics.