Authors
DeStefano, AL
Golbe, LI
Mark, MH
Lazzarini, AM
Maher, NE
Saint-Hilaire, M
Feldman, RG
Guttman, M
Watts, RL
Suchowersky, O
Lafontaine, AL
Labelle, N
Lew, MF
Waters, CH
Growdon, JH
Singer, C
Currie, LJ
Wooten, GF
Vieregge, P
Pramstaller, PP
Klein, C
Hubble, JP
Stacy, M
Montgomery, E
MacDonald, ME
Gusella, JF
Myers, RH
Citation
Al. Destefano et al., Genome-wide scan for Parkinson's disease: The GenePD study, NEUROLOGY, 57(6), 2001, pp. 1124-1126
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878
→ ACNP
Volume
57
Issue
6
Year of publication
2001
Pages
1124 - 1126
Database
ISI
SICI code
0028-3878(20010925)57:6<1124:GSFPDT>2.0.ZU;2-N
Abstract
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling
pairs is reported. Suggestive evidence for linkage was found for chromosom
es 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07),
and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for
dopamine P-hydroxylase and torsion dystonia. Although no strong evidence f
or linkage was found for any locus, these results may be of value in compar
ison with similar studies by others.