TNF alpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS

Authors
Killestein, J Kalkers, NF Meilof, JF Barkhof, F van Lier, RAW Polman, CH
Citation
J. Killestein et al., TNF alpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS, NEUROLOGY, 57(6), 2001, pp. 1129-1131
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
6
Year of publication
2001
Pages
1129 - 1131
Database
ISI
SICI code
0028-3878(20010925)57:6<1129:TAPBCT>2.0.ZU;2-I
Abstract
Reliable laboratory prognostic factors for MS are still lacking. The predic tive value of markers of T-cell activation for long-term disease progressio n was investigated. Flow cytometry measurements were correlated to changes in Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS, A correlation was found between the percentage of tumor necrosis factor-a-producing CD4(+) T cells at base line and the change in T2 lesion load during 3-year follow-up (r = 0.79, ad justed r(2) = 0.59, p = 0.001).