Citation
N. Akamatsu et al., Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats, NEUROSCI L, 310(2-3), 2001, pp. 153-156
Citations number
18
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940
→ ACNP
Volume
310
Issue
2-3
Year of publication
2001
Pages
153 - 156
Database
ISI
SICI code
0304-3940(20010914)310:2-3<153:DSTPSA>2.0.ZU;2-D
Abstract
We studied the effects of I ow-frequency repetitive transcranial magnetic s
timulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at
0.5 Hz led to a prolonged latency for seizure development after an intrape
ritoneal injection of pentylenetetrazol. The rTMS effectively prevented the
development of status epilepticus of pentylenetetrazol-induced convulsions
. These findings indicate that low-frequency rTMS affects the neural excita
bility, in the direction of anticonvulsive, and therefore, suggest the poss
ibility of therapeutic use of rTMS in epilepsy. (C) 2001 Elsevier Science I
reland Ltd. All rights reserved.