Kinin receptor antagonists

Authors
Meini, S Maggi, CA
Citation
S. Meini et Ca. Maggi, Kinin receptor antagonists, PROG R RES, 31, 2001, pp. 137-140
Citations number
31
Categorie Soggetti
Current Book Contents
Journal title
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD → ACNP
ISSN journal
14222140
Volume
31
Year of publication
2001
Pages
137 - 140
Database
ISI
SICI code
1422-2140(2001)31:<137:KRA>2.0.ZU;2-A
Abstract
Kinins are small peptides which are produced in the blood or tissues during inflammation. They act by stimulating distinct receptors, B-1 and B-2. The B-1 receptor is induced during inflammation whereas the B-2 receptor is co nstitutively expressed. Kinins produce a number of effects which are releva nt for airway pathophysiology (bronchoconstriction, plasma protein extravas ation, mucus secretion, stimulation of inflammatory cells). It is currently proposed that kinin receptor antagonists could represent a novel class of drugs useful for the treatment of chronic airway diseases, including asthma .