Neutrophil elastase inhibitors

Authors
Smith, RA Stockley, RA Hodgson, ST
Citation
Ra. Smith et al., Neutrophil elastase inhibitors, PROG R RES, 31, 2001, pp. 173-176
Citations number
25
Categorie Soggetti
Current Book Contents
Journal title
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD → ACNP
ISSN journal
14222140
Volume
31
Year of publication
2001
Pages
173 - 176
Database
ISI
SICI code
1422-2140(2001)31:<173:NEI>2.0.ZU;2-Z
Abstract
Neutrophil elastase has been implicated in COPD for many years. The enzyme has a variety of effects that can contribute to the disease process, partic ularly in lung degradation and mucus secretion. Several approaches have bee n taken to the design and delivery of elastase inhibitors to the lung. The pros and cons of each are discussed in this review.