Chemokine receptors on Th1 and Th2 cells

CD4+ Th1 and Th2 cells are critical mediators of inflammatory diseases. In the lung, Th1-dominated responses are associated with the presence of a lar ge number of macrophages and neutrophils. By contrast, eosinophilic inflamm ation associated with mucus hypersecretion is dependent on the presence of Th2 cells. Here we review the traffic signals that enable the differential remitment of Th1 and Th2 cells for the inflammatory response in the lung.