Inhibition of p38 MAP kinase

The discovery of the p38 mitogen-activated protein kinase (MAPK) signal tra nsduction pathway and identification of specific inhibitors has ushered in a g-rowing area of research into the role of p38 MAPK in pulmonary pathophy siology. Both in vitro and in vivo studies have elucidated the expression o f isoforms of p38 MAPK and suggested an important role in the production an d action of inflammatory cytokines. Further work in this area promises to g ive rise to a deeper understanding of these pathways as well as a potential insight into advances in therapy for both asthma and COPD.