The SRXRF microprobe at the BSRF is described. The minimum detection limits
(MDLs) of trace elements were measured to determine the capability for bio
logical sample analysis. The changes of the trace elements and their ratios
in the normal and tumor parts of a human osteosarcoma tissue were investig
ated. It was found that our results were in agreement with those of other a
nalytical methods, such as spectrophotometric analysis, NAA and PIXE as wel
l as an early clinic study of serum. (C) 2001 Elsevier Science B.V. All rig
hts reserved.