Synthesis and stereochemical characterization of diastereomeric nucleoside-phosphorothioselenoates by NMR methods

Authors
Kajtar-Peredy, M Tomoskozi, I Gacs-Baitz, E
Citation
M. Kajtar-peredy et al., Synthesis and stereochemical characterization of diastereomeric nucleoside-phosphorothioselenoates by NMR methods, NUCLEOS NUC, 20(9), 2001, pp. 1615-1623
Citations number
10
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
9
Year of publication
2001
Pages
1615 - 1623
Database
ISI
SICI code
1525-7770(2001)20:9<1615:SASCOD>2.0.ZU;2-U
Abstract
Synthesis and stereochemical characterization of enantiomerically pure nucl eoside-phosphorothioselenoates are reported. The effects of solvent and tem perature on the vicinal carbon-phosphorus couplings are described and the r esults are interpreted in terms of conformational changes influenced by sta cking interactions between the bases and the phenyl rings.