Synthesis of certain 2 '-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5 '; Evaluation as potential dUTP analogues

Derivatives of 2 ' -deoxyuridine in which the 5 ' -OH group is replaced by a 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy or a 4-carboxy-2,3,6-trifluoro-5 -hydroxyphenoxy group have been prepared for evaluation as possible dUTP an alogues. They showed a weak ability to displace radiolabelled dUTP from a d UTP-binding antiserum. The corresponding compounds lacking the three fluori ne substituents were prepared for comparison.