Citation
Y. Li et al., Synthesis and binding affinity of a chiral PNA analogue, NUCLEOS NUC, 20(9), 2001, pp. 1705-1721
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770
→ ACNP
Volume
20
Issue
9
Year of publication
2001
Pages
1705 - 1721
Database
ISI
SICI code
1525-7770(2001)20:9<1705:SABAOA>2.0.ZU;2-R
Abstract
The synthesis of a chiral peptide nucleic acid (PNA), which is composed of
N-aminoethyl-cis-4-nucleobase-L-proline units, was described. The chiral PN
A monomers containing all four nucleobases (A., T, C and G) were steroselec
tively prepared. The x-ray diffraction data from a single crystal confirmed
the configuration of a key intermediate. Binding activity of the oligomers
with their complementary DNA targets was also investigated.