Inflammatory myofibroblastic tumor with CNS involvement

Background: Inflammatory myofibroblastic tumors (IMT) represent a spectrum of neoplasms that occur in the mesentery and retroperitoneum and less frequ ently in the mediastinum of children and young adults. Transformation into inflammatory fibrosarcoma and metastases are rare. Case Report. We report t he case of a 16-year-old patient with an inflammatory myofibroblastic tumor of the mesentery with mediastinal metastases. Partial remission was obtain ed by chemotherapy with ifosfamide, dactinomycine, and vincristine. Two mon ths later, relapse with infiltration of the meninges developed, and the pat ient died. Conclusion:This case demonstrates unusual features of an IMT. pr esentation with metastases, excellent response to chemotherapy, disseminati on to the CNS.