Loss of KAI1/CD82 expression in bone and soft tissue tumors is not associated with lung metastasis

The KAI1 gene has been identified as a metastasis suppressor gene in human prostate cancer. Decrease or loss of KAI1/CD82 expression has been shown to be associated with poorer prognosis and metastasis in carcinomas of variou s organs. The purpose of this study was to examine whether KAI1/CD82 is exp ressed in bone and soft tissue tumors, and whether it is associated with me tastasis to the lungs. Immunohistochemically, KAI1/CD82 expression in benig n and malignant soft tissue tumors was noted in 83% and 37% of cases, respe ctively. KAI1/CD82 was also expressed in benign bone tumors and osteosarcom as in 67% and 36% of the cases, respectively. Four (40%) of 10 osteosarcoma cases with no lung metastasis and one (25%) of four osteosarcoma cases wit h lung metastasis were positive for KAI1/CD82, respectively. Metastasis of osteosarcoma cells to the lungs was not correlated with the loss of KAI1/CD 82 in osteosarcoma cells.