In two priming experiments, we manipulated the perceptual quality of the ta
rget or the distractor on the prime trial; the stimuli were repeated or nov
el. Negative priming was found to be contingent on stimulus repetition, bec
ause it was obtained with repeated items but not with novel items. Prime tr
ial perceptual degradation modulated negative priming for repeated items bu
t had no effect on priming in ignored repetition conditions using novel sti
muli. These patterns were obtained even when the effect of perceptual degra
dation was (1) greater than the effect of stimulus repetition and (2) great
er for novel words than for repeated words. Although stimulus repetition in
creases perceptual fluency, the activation of perceptual representations by
itself is not sufficient to produce negative priming. Instead, we suggest
that negative printing is a manifestation of an activation-sensitive inhibi
tory mechanism that functions to reduce response competition.