Parameter optimization of temperature field in RF-capacitive hyperthermia

To realize a certain target temperature distribution in tumor tissues and a void over-heating in normal tissues in radio frequency (RF)-capacitive hype rthermia, an objective function and some weight coefficients are introduced . Then using the 2-D finite element method, the electromagnetic and bio-hea t transfer equations are solved, and using the genetic algorithm the heatin g configurations are recursively modified to minimize the objective functio n. Finally an optimum solution of the expected heating field distribution i n hyperthermia is achieved. And with a human heterogeneous tissue model ext racted from X-ray CT images, satisfactory optimization results are obtained in the simulations on a biplate RF-capacitive hyperthermia device. This op timization technique for controlling the body temperature field has shown s cientific importance and practical values in the research of hyperthermia.