We derive a general model, based on principles of biochemical kinetics and
allometry, that characterizes the effects of temperature and body mass on m
etabolic rate. The model fits metabolic rates of microbes, ectotherms, endo
therms; (including those in hibernation), and plants in temperatures rangin
g from 0 degrees to 40 degreesC. Mass- and temperature-compensated resting
metabolic rates of all organisms are similar: The lowest (for unicellular o
rganisms and plants) is separated from the highest (for endothermic vertebr
ates) by a factor of about 20. Temperature and body size are primary determ
inants of biological time and ecological roles.