An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester

Authors
Tian, QP Nayyar, NK Babu, S Chen, LJ Tao, JH Lee, S Tibbetts, A Moran, T Liou, J Guo, M Kennedy, TP
Citation
Qp. Tian et al., An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester, TETRAHEDR L, 42(39), 2001, pp. 6807-6809
Citations number
7
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
39
Year of publication
2001
Pages
6807 - 6809
Database
ISI
SICI code
0040-4039(20010924)42:39<6807:AESOAK>2.0.ZU;2-H
Abstract
An efficient synthetic route to a key intermediate for the preparation of t he rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogr am quantities with an overall yield of 30%. (C) 2001 Elsevier Science Ltd. All rights reserved.