CO2/HCO3--responsive soluble adenylyl cyclase as a putative metabolic sensor

Authors
Zippin, JH Levin, LR Buck, J
Citation
Jh. Zippin et al., CO2/HCO3--responsive soluble adenylyl cyclase as a putative metabolic sensor, TRENDS ENDO, 12(8), 2001, pp. 366-370
Citations number
53
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
TRENDS IN ENDOCRINOLOGY AND METABOLISM
ISSN journal
10432760 → ACNP
Volume
12
Issue
8
Year of publication
2001
Pages
366 - 370
Database
ISI
SICI code
1043-2760(200110)12:8<366:CSACAA>2.0.ZU;2-E
Abstract
Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. R ecently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO3-). As the concentration of HCO3- reflects cellular levels of carbon dioxide (CO2) , energy-generating metabolic processes (which increase intracellular CO2) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserv ed mechanism of metabolic feedback regulation.