Toxicokinetics of ergovaline in the horse after an intravenous administration

The toxicokinetics of ergovaline (an ergopeptine mycotoxin present in some grasses infected with endophytic fungus of the genus Neotyphodium) were stu died after intravenous administration of a single dose of 15 mug/kg bwt in four gelding horses. Plasma ergovaline concentrations were measured by high performance liquid chromatography, and the kinetic data were described by a three-compartment model. The elimination half-life and the total clearanc e of ergovaline were found to be 56.83 +/- 13.48 min and 0.020 +/- 0.004 L/ min kg, respectively. According to the toxicological data previously report ed in the horse, and in spite of the very low dose administered, clinical s igns were observed, including excessive coolness of the ears and the nose, excessive sweating and prostration.