Presence of VZV and HSV-1 DNA in human nodose and celiac ganglia

Authors
Gilden, DH Gesser, R Smith, J Wellish, M Laguardia, JJ Cohrs, RJ Mahalingam, R
Citation
Dh. Gilden et al., Presence of VZV and HSV-1 DNA in human nodose and celiac ganglia, VIRUS GENES, 23(2), 2001, pp. 145-147
Citations number
19
Categorie Soggetti
Molecular Biology & Genetics
Journal title
VIRUS GENES
ISSN journal
09208569 → ACNP
Volume
23
Issue
2
Year of publication
2001
Pages
145 - 147
Database
ISI
SICI code
0920-8569(2001)23:2<145:POVAHD>2.0.ZU;2-S
Abstract
Polymerase chain reaction (PCR) revealed herpes simplex virus (HSV) and var icella zoster virus (VZV) DNA in human nodose and celiac ganglia. This is t he first detection of VZV DNA in ganglia of the human autonomic nervous sys tem. The ability of reactivated VZV to produce serious, sometimes fatal neu rological disease in the absence of rash, raises the possibility that VZV r eactivation from autonomic ganglia might be involved in visceral disease.