Pseudodementia in a twenty-one-year-old with bipolar disorder and vitamin B12 and folate deficiency

A twenty-one-year-old female known to suffer from bipolar type I disorder d eveloped features of a pseudodementia. Following prompt initial response to treatment with antidepressants, there was an early recurrence of cognitive impairment. Blood investigations confirmed a macrocytic anaemia and vitami n B12 and folate deficiencies. There was dramatic resolution of cognitive i mpairment after vitamin replacement. This suggested the occurrence of a rev ersible nutritional dementia and reinforced the need to rule out secondary organic causes of psychiatric symptoms even inpatients previously diagnosed with a primary psychiatric disorder.