Systemic vasculitides (SV) represent a heterogeneous group of different ent
ities with varying clinical and pathological-anatomical characteristics tha
t physicians of diverse disciplines are involved in the treatment of patien
ts with SV. At the onset of disease organ manifestations often present as a
single symptom without appearance of indirect signs of vasculitis as muscu
loskeletal complaints and constitutional symptoms indicating inflammatory s
ystemic disease. Therefore early interdisciplinary care is extremely import
ant to avoid major organ involvement with the development of fatal disease.
Besides the multidisciplinary physical examination serological and immunolo
gical parameters, particularly in small vessel vasculitides are relevant in
establishing the diagnosis. Regarding the interdisciplinary care we differ
entiate between primary diagnostic procedures and continuous followup to ob
serve therapeutic and side effects of medications. Instruments for the asse
ssment of disease extent (DEI), activity (BVAS) and irreversible damage (VD
I) were developed in recent years to document prospectively the disease sta
tus and support activity-adjusted treatment.
Because of the chronic relapsing character of systemic vasculitides, the me
asurement of health-related quality of life gained progressive interest in
the longitudinal follow-up. In addition in these rare diseases early patien
t education with information on the disease, treatment, side effects and tr
aining in self management strategies will enable patients to actively parti
cipate in the management of their disease and bear responsibility.