Two intermediates in the synthesis of decahydroisoquinolines with NMDA andAMPA receptor antagonist activity

In 6-methyl-N-(4-nitrobenzoyl)-5,6-dihydropyridin-2(1H)one, C13H12N2O4, (I) , the piperidone ring is in a distorted half-chair conformation. In 8-metho xy-3-methyl-N-(4-nitrobenzoyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-1,6-di one, C18H20N2O6, (II), the heterocyclic ring is in a slightly distorted hal f-boat conformation, while the other six-membered ring is in a distorted ch air conformation. Compound (II) presents a strong intramolecular C-H . . .O hydrogen bond. In both (I) and (II), the molecules interact through C-H . . .O interactions.