An account is given of the molecular replacement method as implemented in t
he package AMoRe. The overall strategy of the method is presented and the m
ain functions used in the package are described. The most important feature
s of AMoRe are the quality of the fast rotation and translation functions a
nd the facility of multiple inputs to translation and rigid-body refinement
functions, which allow for a fast multiple exploration of crystal configur
ations with a high level of automation.