Radiation proctopathy is a common unfortunate complication following radiat
ion therapy of pelvic malignancies. Symptoms of chronic radiation proctopat
hy include haematochezia, urgency, constipation, tenesmus, diarrhoea and re
ctal pain.
Currently, a wide variety of pharmacological options, endoscopic cautery te
chniques and surgical procedures have been proposed for the treatment of ch
ronic radiation proctopathy. Although these have been proposed primarily as
treatment for rectal bleeding, the control of other symptoms has been note
d with some of these agents. Pharmacological options include 5-aminosalicyl
ic acid preparations, coticosteroid enemas, sucralfate (oral, enemas), form
alin, short chain fatty acid enemas, oestrogen/progesterone, hyperbaric oxy
gen, antioxidants, sodium pentosan polysulphate and misoprostol rectal supp
ositories. Of these, sucralfate and formalin therapy appear to be effective
for bleeding control. Misoprostol rectal suppositories and oral sucralfate
may be useful in the prevention of acute and chronic symptoms of radiation
proctopathy.
Endoscopic cautery techniques have included the use of Nd:YAG laser and arg
on laser for coagulation of bleeding neovascular telangiectasias. Argon pla
sma coagulation offers a safe non-contact method of delivering haemostasis
which has proven to be particularly useful in targeting difficult to reach
lesions tangentially.
Surgery is generally reserved for severe refractory cases involving ongoing
haemorrhage, obstruction, stricture formation, fistulas and perforation. G
iven that formal randomized placebo-controlled studies are lacking for most
treatments, the management of these patients is often challenging and uncl
ear. Hence, there is a need for more research and education on radiation pr
octopathy.