Core safeguards for clinical research with adults who are unable to consent

safeguards for clinical research with adults who are unable to consent. Thr ee other major U.S. groups have also proposed additional safeguards for thi s population, and existing Canadian and European guidelines already include such safeguards. While these six guidelines agree on some safeguards, they disagree on others. To allow Important research to proceed while protectin g adults who are unable to consent, it will be crucial to resolve these dif ferences. This paper uses a side-by-side comparison of these six guidelines to highlight their major points of consensus, analyze their significant di fferences, and distill six core safeguards.