During routine pre-operative evaluation, a 6-month-old infant and an 11-yea
r-old girl were found to have prolonged activated partial thromboplastin ti
me with positive lupus anticoagulants. Both children underwent successful c
ardiac surgery and had no thrombotic or bleeding complications. A literatur
e search revealed that positive lupus anticoagulants can follow minor infec
tions in otherwise asymptomatic children and are benign and self-limiting.
A minority, however, can develop bleeding, thrombosis or an auto-immune dis
order.