M. Fraquelli et al., Gallstone disease and related risk factors in patients with Crohn disease - Analysis of 330 consecutive cases, ARCH IN MED, 161(18), 2001, pp. 2201-2204
Citations number
30
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background: The reported prevalence of gallstone disease (GD), defined as c
urrent gallstones or previous cholecystectomy for gallstones, in patients w
ith Crohn disease ranges from 13% to 34%. The aim of this study was to char
acterize the still undefined risk factors of this complication.
Methods: A total of 330 consecutive patients with Crohn disease (189 males
and 141 females aged 17-82 years, mean +/- SD age, 41 +/- 14 years) underwe
nt liver ultrasonography.
Results: A diagnosis of GD was made in 78 patients (24%), 54 with current g
allstones and 24 who had undergone previous cholecystectomy. Its frequency
was comparable in males and females (23% vs 25%), but was significantly ass
ociated with age (P=.001), being 13%, 36%, and 51% in patients aged 44 year
s and younger, 45 to 59 years, and 60 years and older, respectively (P=.001
). Its prevalence significantly differed according to the site of the disea
se at diagnosis (P=.02) and was unrelated to disease duration. Gallstone di
sease was more frequent in patients who had undergone surgery (34% vs, 14%;
P=.001) and was significantly associated with the number (P=.001) and site
of bowel resections (P=.001), increasing from 28% in the patients who had
undergone 1 resection to 53% in those having had 2 or more resections (P=.0
05) and being significantly higher in patients with a resection involving t
he ileocecal region. Multivariate analysis showed that age; site of disease
at diagnosis; and the presence, number, and site of bowel resections were
significantly related to GD.
Conclusions: In patients with Crohn disease, the frequency of GD is signifi
cantly higher than that reported in the general population with comparable
characteristics (z = 5.04, P < .001). Age; site of disease at diagnosis; an
d the history, number, and site of bowel resections are independently assoc
iated with GD.