We report on deep multi-color imaging (R-5 sigma = 26) of the Chandra Deep
Field South, obtained with the Wide Field Imager (WFI) at the MPG/ESO 2.2 m
telescope on La Silla as part of the multi-color survey COMBO-17. As a res
ult we present a catalogue of 63 501 objects in a field measuring 31.'5 x 3
0' with astrometry and BVR photometry. A sample of 37 variable objects is s
elected from two-epoch photometry. We try to give interpretations based on
color and variation amplitude.