We present times series of high resolution spectra of AGB variables at 4 mu
m. Line profiles from the major contributors to the spectra of oxygen-rich
stars at 4 mum, OH, H2O, HCl and SiO, are examined. The velocity as well as
shape variations of these profiles with time are discussed. The line profi
les investigated frequently have emission and multiple absorption component
s. The changes with time of the 4 mum region lines do not always follow the
cyclic variability seen in NIR spectra and in the photometric light curve.
We interpret and discuss the results qualitatively considering comparing t
he spectral variability with that of the well behaved 1.6 mum region and of
dynamical model atmospheres. Miras and semiregular variables are compared.
The origins of non-periodic behavior are discussed, including the role of
spatial inhomogeneities in the stellar atmosphere.