ASYMMETRIC ANGIONEUROTIC-EDEMA ASSOCIATED WITH THROMBOLYSIS FOR ACUTESTROKE

We present a case of acute asymmetric angioneurotic edema associated w ith the use of recombinant tissue plasminogen activator (rtPA) for acu te ischemic stroke. rtPA was administered for an acute ischemic stroke in accordance with the recently reported National Institute of Neurol ogical Disorders and Stroke protocol, after which marked asymmetric an gioedema requiring upper-airway control developed. Although atypical a nd anaphylactoid reactions have been reported with the use of rtPA for acute myocardial infarction, to our knowledge this is the first case report of asymmetric angioedema associated with the use of rtPA for ac ute ischemic stroke.