A. Pancioli et al., ASYMMETRIC ANGIONEUROTIC-EDEMA ASSOCIATED WITH THROMBOLYSIS FOR ACUTESTROKE, Annals of emergency medicine, 30(2), 1997, pp. 227-229
We present a case of acute asymmetric angioneurotic edema associated w
ith the use of recombinant tissue plasminogen activator (rtPA) for acu
te ischemic stroke. rtPA was administered for an acute ischemic stroke
in accordance with the recently reported National Institute of Neurol
ogical Disorders and Stroke protocol, after which marked asymmetric an
gioedema requiring upper-airway control developed. Although atypical a
nd anaphylactoid reactions have been reported with the use of rtPA for
acute myocardial infarction, to our knowledge this is the first case
report of asymmetric angioedema associated with the use of rtPA for ac
ute ischemic stroke.