In humans, the emotional nature of stimuli appears to have a complex influe
nce on long-term declarative memory for those stimuli: Whereas emotion enha
nces memory for gist, it may suppress memory for detail. On the basis of pr
ior studies, the authors hypothesized that the amygdala helps mediate the a
bove 2 effects. Long-term memory for gist and for visual detail of aversive
and neutral scenes was assessed in 20 subjects with unilateral amygdala da
mage and 1 rare subject with bilateral amygdala damage. Comparisons with 2
control groups (15 brain-damaged and 47 healthy) provided evidence that bil
ateral, but not unilateral, damage to the amygdala results in poorer memory
for gist but superior memory for visual details. The pattern of findings p
rovides preliminary support for the idea that the amygdala may help filter
the encoding of relevant information from stimuli that signal threat or dan
ger.