Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine

Authors
Sun, XL Liu, HB Orban, JM Sun, LJ Chaikof, EL
Citation
Xl. Sun et al., Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine, BIOCONJ CHE, 12(5), 2001, pp. 673-677
Citations number
33
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOCONJUGATE CHEMISTRY
ISSN journal
10431802 → ACNP
Volume
12
Issue
5
Year of publication
2001
Pages
673 - 677
Database
ISI
SICI code
1043-1802(200109/10)12:5<673:SATFOA>2.0.ZU;2-Z
Abstract
We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such a s biotin or N-(epsilon -maleimidocaproyl (EMC), to facilitate bioconjugatio n reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-sit u photocopolymerization.